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Nat Chem Biol. 2011 Oct 2;7(11):766-8. doi: 10.1038/nchembio.667.

Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4.

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1
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA.

Abstract

Cytokinins are classic hormones that orchestrate plant growth and development and the integrity of stem cell populations. Cytokinin receptors are eukaryotic sensor histidine kinases that are activated by both naturally occurring adenine-type cytokinins and urea-based synthetic compounds. Crystal structures of the Arabidopsis thaliana histidine kinase 4 sensor domain in complex with different cytokinin ligands now rationalize the hormone-binding specificity of the receptor and may spur the design of new cytokinin ligands.

PMID:
21964459
PMCID:
PMC3197759
DOI:
10.1038/nchembio.667
[Indexed for MEDLINE]
Free PMC Article
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