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Biochem Biophys Res Commun. 2011 Oct 22;414(2):277-81. doi: 10.1016/j.bbrc.2011.09.080. Epub 2011 Sep 22.

Cell death pathology: cross-talk with autophagy and its clinical implications.

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1
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK.

Abstract

Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, "autophagic cell death". Thus, autophagy can act both as a temporary protective mechanism during a brief stressful episode and be a mode of cell death in its own right. In this mini-review we focus on recent knowledge concerning the connection between autophagy and programmed cell death, evaluating their possible implications for therapy in pathologies like cancer and neurodegeneration.

PMID:
21963447
DOI:
10.1016/j.bbrc.2011.09.080
[Indexed for MEDLINE]
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