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Curr Opin Cell Biol. 2011 Dec;23(6):744-55. doi: 10.1016/j.ceb.2011.09.003. Epub 2011 Sep 29.

mTOR signaling in disease.

Author information

1
Biozentrum, University of Basel, CH4056 Basel, Switzerland.

Abstract

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.

PMID:
21963299
DOI:
10.1016/j.ceb.2011.09.003
[Indexed for MEDLINE]

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