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Mol Cell. 2011 Oct 21;44(2):235-51. doi: 10.1016/j.molcel.2011.09.002. Epub 2011 Sep 29.

BRCA1 is required for postreplication repair after UV-induced DNA damage.

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1
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Abstract

BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR.

PMID:
21963239
PMCID:
PMC3200447
DOI:
10.1016/j.molcel.2011.09.002
[Indexed for MEDLINE]
Free PMC Article
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