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Curr Opin Neurobiol. 2012 Jun;22(3):383-8. doi: 10.1016/j.conb.2011.09.002. Epub 2011 Sep 28.

Structural plasticity of dendritic spines.

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1
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Dendritic spines are small mushroom-like protrusions arising from neurons where most excitatory synapses reside. Their peculiar shape suggests that spines can serve as an autonomous postsynaptic compartment that isolates chemical and electrical signaling. How neuronal activity modifies the morphology of the spine and how these modifications affect synaptic transmission and plasticity are intriguing issues. Indeed, the induction of long-term potentiation (LTP) or depression (LTD) is associated with the enlargement or shrinkage of the spine, respectively. This structural plasticity is mainly controlled by actin filaments, the principal cytoskeletal component of the spine. Here we review the pioneering microscopic studies examining the structural plasticity of spines and propose how changes in actin treadmilling might regulate spine morphology.

PMID:
21963169
PMCID:
PMC4281347
DOI:
10.1016/j.conb.2011.09.002
[Indexed for MEDLINE]
Free PMC Article
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