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Trends Immunol. 2011 Nov;32(11):548-58. doi: 10.1016/j.it.2011.08.001. Epub 2011 Sep 29.

DRiPs solidify: progress in understanding endogenous MHC class I antigen processing.

Author information

1
Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA. jyewdell@nih.gov

Abstract

Defective ribosomal products (DRiPs) are a subset of rapidly degraded polypeptides that provide peptide ligands for major histocompatibility complex (MHC) class I molecules. Here, recent progress in understanding DRiP biogenesis is reviewed. These findings place DRiPs at the center of the MHC class I antigen processing pathway, linking immunosurveillance of viruses and tumors to mechanisms of specialized translation and cellular compartmentalization. DRiPs enable the immune system to rapidly detect alterations in cellular gene expression with great sensitivity.

PMID:
21962745
PMCID:
PMC3200450
DOI:
10.1016/j.it.2011.08.001
[Indexed for MEDLINE]
Free PMC Article

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