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Brain Res. 2011 Oct 28;1420:1-7. doi: 10.1016/j.brainres.2011.08.078. Epub 2011 Sep 7.

Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex.

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  • 1Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA. bwinters@vetmed.wsu.edu

Abstract

Despite sleep-loss-induced cognitive deficits, little is known about the cellular adaptations that occur with sleep loss. We used brain slices obtained from mice that were sleep deprived for 8h to examine the electrophysiological effects of sleep deprivation (SD). We employed a modified pedestal (flowerpot) over water method for SD that eliminated rapid eye movement sleep and greatly reduced non-rapid eye movement sleep. In layer V/VI pyramidal cells of the medial prefrontal cortex, miniature excitatory post synaptic current amplitude was slightly reduced, miniature inhibitory post synaptic currents were unaffected, and intrinsic membrane excitability was increased after SD.

PMID:
21962531
PMCID:
PMC3205322
DOI:
10.1016/j.brainres.2011.08.078
[PubMed - indexed for MEDLINE]
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