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Blood. 2011 Dec 15;118(25):6499-505. doi: 10.1182/blood-2011-07-370742. Epub 2011 Sep 29.

The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells.

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Commissariat a l'Energie Atomique et aux Energies Alternatives-Institute d'Imagerie Biomedicale, Service de Recherches en Hemato-Immunologie, Hopital Saint Louis, 1 Avenue Claude Vellejause, Paris Cedex, France.


Myeloid antigen-presenting cells (APCs), regulatory cells, and the HLA-G molecule are involved in modulating immune responses and promoting tolerance. APCs are known to induce regulatory cells and to express HLA-G as well as 2 of its receptors; regulatory T cells can express and act through HLA-G; and HLA-G has been directly involved in the generation of regulatory cells. Thus, interplay(s) among HLA-G, APCs, and regulatory cells can be easily envisaged. However, despite a large body of evidence on the tolerogenic properties of HLA-G, APCs, and regulatory cells, little is known on how these tolerogenic players cooperate. In this review, we first focus on key aspects of the individual relationships between HLA-G, myeloid APCs, and regulatory cells. In its second part, we highlight recent work that gathers individual effects and demonstrates how intertwined the HLA-G/myeloid APCs/regulatory cell relationship is.

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