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Chem Commun (Camb). 2012 Feb 1;48(10):1514-6. doi: 10.1039/c1cc14711k. Epub 2011 Sep 30.

Facile synthesis and altered ionization efficiency of diverse Nε-alkyllysine-containing peptides.

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1
Tri-Institutional Training Program in Chemical Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Protein lysine methylation is a biologically-important posttranslational modification. Given the increased use of alkyllysine-containing peptides to study protein methylation, we describe an efficient solid-phase synthesis to access various alkyllysine-containing peptides. As an exemplary application, we evaluated how ionization efficiency of the alkyllysine peptides affects mass spectrometric analysis.

PMID:
21959946
PMCID:
PMC3573693
DOI:
10.1039/c1cc14711k
[Indexed for MEDLINE]
Free PMC Article
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