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Biochim Biophys Acta. 2012 Feb;1818(2):272-85. doi: 10.1016/j.bbamem.2011.09.007. Epub 2011 Sep 16.

Structural correlates of selectivity and inactivation in potassium channels.

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1
Department of Anesthesiology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA.

Abstract

Potassium channels are involved in a tremendously diverse range of physiological applications requiring distinctly different functional properties. Not surprisingly, the amino acid sequences for these proteins are diverse as well, except for the region that has been ordained the "selectivity filter". The goal of this review is to examine our current understanding of the role of the selectivity filter and regions adjacent to it in specifying selectivity as well as its role in gating/inactivation and possible mechanisms by which these processes are coupled. Our working hypothesis is that an amino acid network behind the filter modulates selectivity in channels with the same signature sequence while at the same time affecting channel inactivation properties. This article is part of a Special Issue entitled: Membrane protein structure and function.

PMID:
21958666
PMCID:
PMC3253935
DOI:
10.1016/j.bbamem.2011.09.007
[Indexed for MEDLINE]
Free PMC Article
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