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Exp Oncol. 2011 Sep;33(3):162-4.

Pristine C(60) fullerenes inhibit the rate of tumor growth and metastasis.

Author information

1
Taras Shevchenko National University of Kyiv, Institute of Biology, Volodymyrska Str., 64, 01601 Kyiv, Ukraine. prylut@ukr.net

Abstract

AIM:

To estimate the impact of C(60) fullerene aqueous solution (C(60)FAS) on the rate of transplanted malignant tumor growth and metastasis.

METHODS:

Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used.

RESULTS:

The C(60)FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%.

CONCLUSION:

It was found that water-soluble pristine С(60) fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis.

PMID:
21956470
[Indexed for MEDLINE]

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