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Analyst. 2011 Nov 21;136(22):4670-3. doi: 10.1039/c1an15684e. Epub 2011 Sep 29.

High throughput plasma N-glycome profiling using multiplexed labelling and UPLC with fluorescence detection.

Author information

1
Genos Ltd, Laboratory for Glycobiology, Zagreb, Croatia.

Abstract

A rapid glycomic profiling method is described wherein N-glycans from plasma samples individually labelled with aniline, 2-aminobenzamide and 2-aminoacridone are mixed, co-injected and separated in the same HILIC-fluorescence run. Transfer of the multiplexed method to UPLC-fluorescence permits an increase in sample throughput from 24 to 864 plasma samples per day.

PMID:
21956149
DOI:
10.1039/c1an15684e
[Indexed for MEDLINE]

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