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Bioorg Med Chem Lett. 2011 Nov 1;21(21):6348-52. doi: 10.1016/j.bmcl.2011.08.106. Epub 2011 Aug 31.

Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.

Author information

1
Pfizer Global Research and Development, 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. robowenhughes@gmail.com

Abstract

We describe the design, synthesis and profiling of a novel series of PDE5 inhibitors. We take advantage of an alternate projection into the solvent region to identify compounds with excellent potency, selectivity and pharmacokinetic profiles.

PMID:
21955943
DOI:
10.1016/j.bmcl.2011.08.106
[Indexed for MEDLINE]

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