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Curr Opin Genet Dev. 2011 Dec;21(6):740-6. doi: 10.1016/j.gde.2011.09.007. Epub 2011 Sep 28.

Symmetry breaking and the establishment of cell polarity in budding yeast.

Author information

1
Duke University Medical Center, Durham, NC, USA.

Abstract

Cell polarity is typically oriented by external cues such as cell-cell contacts, chemoattractants, or morphogen gradients. In the absence of such cues, however, many cells can spontaneously polarize in a random direction, suggesting the existence of an internal polarity-generating mechanism whose direction can be spatially biased by external cues. Spontaneous 'symmetry-breaking' polarization is likely to involve an autocatalytic process set off by small random fluctuations. Here we review recent work on the nature of the autocatalytic process in budding yeast and on the question of why polarized cells only develop a single 'front'.

PMID:
21955794
PMCID:
PMC3224179
DOI:
10.1016/j.gde.2011.09.007
[Indexed for MEDLINE]
Free PMC Article

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