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Pharmacol Ther. 1990;47(1):61-71.

Glutathione-dependent protection against oxidative injury.

Author information

1
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322.

Abstract

Functions of GSH in detoxication during radical-induced injury in specific pathological and toxicological conditions are discussed. GSH protects against oxidative damage in systems that scavenge radicals, eliminate lipid peroxidation products, preserve thiol-disulfide status of proteins, and repair oxidant damage. Several factors which affect cellular GSH homeostasis can affect these functions, including nutritional status, hypoxia and pharmacological intervention. Evidence from a variety of pathological and toxicological conditions, e.g. ischemia-reperfusion injury, chemically induced oxidative injury, radiation damage, aging, and degenerative diseases, indicate that GSH is a primary component of physiological systems to protect against oxidant and free-radical-mediated cell injury.

PMID:
2195557
DOI:
10.1016/0163-7258(90)90045-4
[Indexed for MEDLINE]

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