Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Chem Soc. 2011 Oct 26;133(42):16718-21. doi: 10.1021/ja2083587. Epub 2011 Sep 30.

On-demand electrochemical activation of the click reaction on self-assembled monolayers on gold presenting masked acetylene groups.

Author information

  • 1Department of Bioscience and Biotechnology, School of Physics, Konkuk University, Seoul 143-701, Korea.

Abstract

We report on a new surface modification method for grafting a "dynamic" property for on-demand activation of the click reaction. Our approach utilizes the acetylene group masked with dicobalt hexacarbonyl, Co(2)(CO)(6), which is not reactive toward the click reaction. Electrochemical treatment reveals the acetylene group on the selected region, which is then used as a chemical handle for surface functionalization via the click reaction with an azide-containing molecule. Electrochemical and chemical conversions on the surface were verified by cyclic voltammetry, X-ray photoelectron spectroscopy, and fluorescence spectroscopy. We have demonstrated immobilization of an azide-modified RGD peptide and promotion of cell adhesion/migration to the region of electrochemical induction.

PMID:
21954977
DOI:
10.1021/ja2083587
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center