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Morfologiia. 2011;139(3):41-5.

[Changes the TRPV1-immunoreactive neurons of the rat spinal nerve sensory ganglia induced by capsaicin].

[Article in Russian]


Morphological features of the TRPV1-immunoreactive neurons were studied in thoracic spinal nerve sensory ganglion in 10-, 20-, 30-, 60- and 90-day-old rats under normal conditions and after chemical deafferentation caused by capsaicin (100 mg/kg) subcutaneous injection at postnatal day 2. TRPV1-immunoreactive neurons differed in their morphometric characteristics: positive neurons had very small and small sizes, negative cells had the small, medium and large sizes. Capsaicin treatment of newborn rats was shown to change age dynamics of TRPV1-positive neurons resulting in the reduction of the average cell cross-sectional area and cell numbers during the whole period of observation.

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