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Bratisl Lek Listy. 2011;112(10):591-4.

Class II alleles HLA-DQB1* 0301 among a seven-membered Egyptian family of a child with oral pemphigoid.

Author information

  • 1Oro-dental Genetics Department, Division of Oral and Dental Medicine research National Research Centre, Cairo, Egypt. mostafanrc@yahoo.com

Abstract

OBJECTIVES:

The presence of HLA-DBQ1* 0301 allele in an Egyptian patient with oral pemphigoid and six of his family members was investigated.

BACKGROUND:

Oral pemphigoid is a variant of vesiculobullous mucous membrane pemphigoid with an immunogenetic predisposition related to defects in major histocompatibility complex (OMIM 604305), HLA-DQB 1 alleles.

METHODS:

High resolution typing of HLA-DQB 1*0301 allele was carried out for the seven members of an Egyptian family including the child affected with oral pemphigoid.

RESULTS:

Both parents and three children including the proband were found to be carriers for the studied allele, while the other two children were not.

CONCLUSION:

Participation of HLA-DBQ1*0301 allele was not informative for both susceptibility and/or phenotypic expression of the disease within the studied family (Fig. 2, Ref. 31).

PMID:
21954547
[PubMed - indexed for MEDLINE]
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