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Eur J Immunol. 2011 Oct;41(10):2817-9. doi: 10.1002/eji.201142055.

New insights into cathelicidin modulation of adaptive immunity.

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Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4.


Cathelicidins are a family of host defence peptides that are known to selectively alter innate immunity in response to infection and other changes in immune status. A study in this issue of the European Journal of Immunology elucidates a new role for mouse cathelin-related antimicrobial peptide in the adaptive immune response by clearly demonstrating for the first time that a cathelicidin can alter T-cell-dependent activation of the humoral response in vivo and thus modulate the activities of both B and T lymphocytes.

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