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J Am Soc Mass Spectrom. 2011 Jun;22(6):960-8. doi: 10.1007/s13361-011-0094-z. Epub 2011 Mar 8.

Mass spectrometric immunoassay revisited.

Author information

1
Molecular Biomarkers, The Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA. randal.nelson@asu.edu

Abstract

The progressive understanding and improvement of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS), realized over the years through the considerable efforts of Dr. Marvin Vestal, have made possible numerous comparable efforts involving its application in the biological sciences. Here we revisit the concepts behind one such analytical approach, Mass Spectrometric Immunoassay, which is designed to selectively detect and quantify proteins present in biological milieu.

PMID:
21953037
PMCID:
PMC3761394
DOI:
10.1007/s13361-011-0094-z
[Indexed for MEDLINE]
Free PMC Article

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