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Eur J Immunol. 2011 Sep;41(9):2472-6. doi: 10.1002/eji.201141715.

F4/80 and the related adhesion-GPCRs.

Author information

1
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. siamon.gordon@path.ox.ac.uk

Abstract

The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.

PMID:
21952799
DOI:
10.1002/eji.201141715
[Indexed for MEDLINE]
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