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J Vet Med Sci. 2012 Feb;74(2):231-4. Epub 2011 Sep 28.

Comparison of behavioral effects of morphine and fentanyl in dogs and cats.

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Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan.


Behavioral effects induced by intravenous administration of morphine at 0.3, 0.6, 1.2, and 2.4 µg/kg and fentanyl at 5, 10, 20, and 40 µg/kg were evaluated in dogs and cats. In dogs, fentanyl and morphine depressed activity and level of consciousness in a dose- dependant manner. In cats, higher doses of fentanyl stimulated activity temporarily, but excitement, so-called "opioid mania," was not observed. Morphine induced distinctive behavioral changes characterized by sitting with fixed staring, and "opioid mania" was not observed in cats.

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