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Methods Cell Biol. 2011;105:493-516. doi: 10.1016/B978-0-12-381320-6.00021-7.

Chemical screening in zebrafish for novel biological and therapeutic discovery.

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1
Stem Cell Program and Division of Hematology and Oncology, Children’s Hospital Boston, Dana-Farber Cancer Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, Massachusetts, USA

Abstract

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost-effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.

[Indexed for MEDLINE]

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