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Methods Cell Biol. 2011;105:117-36. doi: 10.1016/B978-0-12-381320-6.00005-9.

Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis.

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Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.


Hematopoietic stem cells (HSC) form the basis of the hematopoietic hierarchy, giving rise to each of the blood lineages found throughout the lifetime of the organism. The genetic programs regulating HSC development are highly conserved between vertebrate species. The zebrafish has proven to be an excellent model for discovering and characterizing the signaling networks and physical forces regulating vertebrate hematopoietic development.

[Indexed for MEDLINE]

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