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Eur J Clin Invest. 2012 May;42(5):463-9. doi: 10.1111/j.1365-2362.2011.02601.x. Epub 2011 Sep 23.

Plasma myeloperoxidase level and peripheral arterial disease.

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1
Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria.

Abstract

BACKGROUND:

Myeloperoxidase (MPO) is involved in a multitude of inflammatory processes involving oxidative modification of soluble components and cellular surfaces. Thus, MPO plays a key role in promoting atherosclerosis via oxidative stress by modification of both high- and low-density lipoprotein and production of other bioactive molecules. A polymorphism (MPO 463G>A, rs2333227) results in different expression rates of MPO. We aimed to assess whether MPO could be of clinical use as a risk marker for vascular disease in a high-risk group.

MATERIAL AND METHODS:

Plasma MPO levels of 406 patients suffering from peripheral arterial disease (PAD) were measured on an Abbott Architect i2000sr and grouped into patients with high (>115 ng/mL) and low (< 115 ng/mL) MPO levels. Genotyping of rs2333227 was performed on an ABI TaqMan 7900HT RT-PCR thermocycler.

RESULTS:

The relative risk of major adverse cardiovascular events (MACE) for patients with high plasma MPO is 1.2 (95%CI: 1.038-1.377, P < 0.05), initial event-free periods in male patients are significantly longer in patients with MPO <115 ng/mL (mean = 875 days compared with mean = 734 days, P < 0.05) In smokers, an increased hazard ratio was computed for patients with high MPO levels (HR = 3.127, 95%CI: 1.258-7.772, P < 0.05). Effects of MPO [-463A] allele on initial MACE-free intervals did not persist after multivariate analysis.

CONCLUSIONS:

Hence, we suggest consideration of plasma MPO for risk stratification of MACE in patients with PAD. In contrast, MPO-463G>A is not an independent risk factor for MACE in patients suffering from PAD.

[Indexed for MEDLINE]

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