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J Biomed Opt. 2011 Sep;16(9):090502. doi: 10.1117/1.3625231.

Laser speckle contrast imaging of cerebral blood flow in freely moving animals.

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  • 1Shanghai Jiao Tong University, School of Biomedical Engineering, 800 Dongchuan Road, Shanghai, 200240, China.


We designed a miniature laser speckle imager that weighs ∼20 g and is 3.1-cm high for full-field high-resolution imaging of cerebral blood flow (CBF) in freely moving animals. Coherent laser light illuminates the cortex through a multimode optical fiber bundle fixed onto the supporting frame of the imager. The reflected lights are then collected by a miniature macrolens system and imaged by a high-resolution CMOS camera at a high frame rate (50 fps). Using this miniature imager, we achieve high spatiotemporal resolution laser speckle contrast imaging of CBF in freely moving animals in real time.

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