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Ann N Y Acad Sci. 2011 Sep;1232:381-91. doi: 10.1111/j.1749-6632.2011.06062.x.

Molecular mechanisms of Barrett's esophagus and adenocarcinoma.

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Department of Cell Biology and Anatomy, College of Medicine, Tucson, Arizona, USA.


The following on molecular mechanisms of Barrett's esophagus and adenocarcinoma contains commentaries on the mechanism of bile and gastric acid induced damage; the roles of BMP-4 and CDX-2 in the development of intestinal metaplasia; the transcription factors driving intestinalization in Barrett's esophagus; the contribution of bone marrow to metaplasia and adenocarcinoma; activation and inactivation of transcription factors; and a novel study design targeting molecular pathways in Barrett's esophagus.

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