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Muscle Nerve. 2011 Sep;44(3):318-31. doi: 10.1002/mus.22094.

Structure and function of the skeletal muscle extracellular matrix.

Author information

1
Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0863, USA.

Abstract

The skeletal muscle extracellular matrix (ECM) plays an important role in muscle fiber force transmission, maintenance, and repair. In both injured and diseased states, ECM adapts dramatically, a property that has clinical manifestations and alters muscle function. Here we review the structure, composition, and mechanical properties of skeletal muscle ECM; describe the cells that contribute to the maintenance of the ECM; and, finally, overview changes that occur with pathology. New scanning electron micrographs of ECM structure are also presented with hypotheses about ECM structure–function relationships. Detailed structure–function relationships of the ECM have yet to be defined and, as a result, we propose areas for future study.

KEYWORDS:

Skeletal muscle; biomechanics; collagen; extracellular matrix; fibrosis

PMID:
21949456
PMCID:
PMC3177172
DOI:
10.1002/mus.22094
[Indexed for MEDLINE]
Free PMC Article

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