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Nucleic Acids Res. 2012 Jan;40(Database issue):D605-9. doi: 10.1093/nar/gkr796. Epub 2011 Sep 24.

BμG@Sbase--a microbial gene expression and comparative genomic database.

Author information

1
Bacterial Microarray Group, Centre for Infection & Immunity, Division of Clinical Sciences, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK. awitney@sgul.ac.uk

Abstract

The reducing cost of high-throughput functional genomic technologies is creating a deluge of high volume, complex data, placing the burden on bioinformatics resources and tool development. The Bacterial Microarray Group at St George's (BμG@S) has been at the forefront of bacterial microarray design and analysis for over a decade and while serving as a hub of a global network of microbial research groups has developed BμG@Sbase, a microbial gene expression and comparative genomic database. BμG@Sbase (http://bugs.sgul.ac.uk/bugsbase/) is a web-browsable, expertly curated, MIAME-compliant database that stores comprehensive experimental annotation and multiple raw and analysed data formats. Consistent annotation is enabled through a structured set of web forms, which guide the user through the process following a set of best practices and controlled vocabulary. The database currently contains 86 expertly curated publicly available data sets (with a further 124 not yet published) and full annotation information for 59 bacterial microarray designs. The data can be browsed and queried using an explorer-like interface; integrating intuitive tree diagrams to present complex experimental details clearly and concisely. Furthermore the modular design of the database will provide a robust platform for integrating other data types beyond microarrays into a more Systems analysis based future.

PMID:
21948792
PMCID:
PMC3245117
DOI:
10.1093/nar/gkr796
[Indexed for MEDLINE]
Free PMC Article
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