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Adv Exp Med Biol. 2012;946:55-68. doi: 10.1007/978-1-4614-0106-3_4.

Interaction of the microbiome with the innate immune response in chronic wounds.

Author information

1
Epithelial Biology Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-4442, USA. gricee@mail.nih.gov

Abstract

Microbes colonizing and/or infecting chronic wounds undoubtedly play a major and interactive role in impaired healing, especially in amplifying and perpetuating the host innate immune response. The development of molecular techniques to identify and quantify microbial organisms has revolutionized our view of the microbial world. These less-biased, high throughput methods greatly enable investigations regarding host-microbe interactions in the chronic wound environment. This review focuses on the mounting evidence implicating microbes and excessive inflammation in chronic wounds, as well as the challenges associated with understanding how microbes modulate wound healing and the innate immune response.

PMID:
21948362
PMCID:
PMC3516280
DOI:
10.1007/978-1-4614-0106-3_4
[Indexed for MEDLINE]
Free PMC Article

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