Format

Send to

Choose Destination
See comment in PubMed Commons below
Virchows Arch. 2011 Nov;459(5):547-53. doi: 10.1007/s00428-011-1148-0. Epub 2011 Sep 23.

High-resolution genomic profiling of an adult Wilms' tumor: evidence for a pathogenesis distinct from corresponding pediatric tumors.

Author information

1
Department of Clinical Genetics, BMC B13, University and Regional Laboratories, Lund University, 221 84 Lund, Sweden. jenny.karlsson@med.lu.se

Abstract

Wilms' tumor (WT), the most common kidney tumor among children, is characterized by a triphasic morphology consisting of blastemal, epithelial, and stromal components. Adult WT is a rare malignancy displaying similar histological features. We here present the first published high-resolution genomic analysis of a mixed-type adult WT. This revealed a more pronounced genetic complexity than usually observed in children with mixed-type WT. The majority of chromosomes displayed uniparental disomies, and microdeletions were present in genes with known importance for tumor formation (LRP1B, FHIT, and WWOX) or organogenesis (NEGR1 and ZFPM2), abnormalities not previously reported for pediatric WT. Our results indicate that adult WT is a biological entity distinct from the corresponding pediatric tumor type.

PMID:
21947875
DOI:
10.1007/s00428-011-1148-0
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center