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Exp Gerontol. 2011 Dec;46(12):987-93. doi: 10.1016/j.exger.2011.09.001. Epub 2011 Sep 16.

Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.

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Genetics Department, National Institutes of Geriatrics, Beijing Hospital, Ministry of Health P.R. China.


Human longevity is a complex heritable genetic trait. Based on substantial evidence from model organisms, it is clear that mitochondria play a pivotal role in aging and lifespan. However, the effects that mitochondrial genome variations have upon longevity and longevity-related phenotypes in Chuang people in China have yet to be established. By genotyping 15 variants for 10 haplogroups in 738 Chuang subjects, including 367 long-lived individuals and 371 controls, we found that haplogroup F was significantly associated with longevity in females of Zhuang population of China (p=0.003, OR: 2.01, 95%CI: 1.263-3.197). Additionally, haplogroup F was related to higher HDL levels (p<0.05) in long-lived individuals. Further analysis suggests that the non-synonymous variant m.13928G>C in haplogroup F was also associated with longevity in female Zhuang Chinese which might account for the beneficial effect of F.

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