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Methods Enzymol. 2011;500:411-33. doi: 10.1016/B978-0-12-385118-5.00021-9.

Whole-genome metabolic network reconstruction and constraint-based modeling.

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Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.


With the advent of modern high-throughput genomics, there is a significant need for genome-scale analysis techniques that can assist in complex systems analysis. Metabolic genome-scale network reconstructions (GENREs) paired with constraint-based modeling are an efficient method to integrate genomics, transcriptomics, and proteomics to conduct organism-specific analysis. This text explains key steps in the GENRE construction process and several methods of constraint-based modeling that can help elucidate basic life processes and development of disease treatment, bioenergy solutions, and industrial bioproduction applications.

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