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Int J Tuberc Lung Dis. 2011 Sep;15(9):1246-51, i. doi: 10.5588/ijtld.11.0031.

Association between the interleukin-18 promoter polymorphism and pulmonary tuberculosis in a Korean population.

Author information

1
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Abstract

OBJECTIVE:

To examine the role of the -667G/T, -618A/C and -148G/C single nucleotide polymorphisms in the promoter region of the human interleukin (IL) 18 gene in the development of pulmonary tuberculosis (PTB), and its radiographic characteristics and severity.

DESIGN:

Differences in the allele and genotype distributions of the -667G/T, -618A/C, and -148G/C polymorphisms between 251 patients with PTB and 225 healthy controls, between patients with single- and multilobe involvement, and between patients with and without cavities were explored. Serum IL-18 levels were measured using an enzyme-linked immunosorbent assay.

RESULTS:

The -148G/G genotype was more common in patients with cavities than in those without (82.8% vs. 70.9%, P = 0.04), but an analogous trend was not observed for the -667G/T and -618A/C genotypes. However, there were no significant differences in allele and genotype distributions between patients with PTB and healthy controls, or between patients with single- and multilobe involvement (P > 0.05). Serum IL-18 levels were higher in patients with cavities (P = 0.01) and in patients with the -148G/G genotype (P = 0.02).

CONCLUSION:

Considering serum IL-18 levels, the -148G/G genotype is associated with a cavitary formation of PTB rather than its development.

PMID:
21943853
DOI:
10.5588/ijtld.11.0031
[Indexed for MEDLINE]

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