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Parasit Vectors. 2011 Sep 27;4:186. doi: 10.1186/1756-3305-4-186.

Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease.

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Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Zoonosis Research Centre of State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Changchun 130062, People's Republic of China.


Helminth infection may modulate the expression of Toll like receptors (TLR) in dendritic cells (DCs) and modify the responsiveness of DCs to TLR ligands. This may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (IBD). Epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. Fine control of inflammation in the TLR pathway is highly desirable for effective host defense. Thus, the use of antagonists of TLR-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of IBD.

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