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Annu Rev Genet. 2011;45:431-45. doi: 10.1146/annurev-genet-102209-163607. Epub 2011 Sep 19.

Genomic analysis at the single-cell level.

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1
Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA. quake@stanford.edu

Abstract

Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.

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