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Case Rep Dermatol. 2011 May;3(2):164-9. doi: 10.1159/000331324. Epub 2011 Aug 17.

Malignant fibrous histiocytoma with in-transit metastasis.

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Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.


Malignant fibrous histiocytoma (MFH) is the most common fibroblastic tumor, but its cutaneous metastasis, especially in-transit metastasis, is extremely rare. We describe the case of a 30-year-old Japanese man with a recurrent MFH on the scalp accompanied by in-transit metastasis, which had been treated as a benign skin tumor 8 years before. The main bulk of the recurrent tumor was located in the dermis, but the metastatic tumor was mainly located in the subcutis. Generally, atypical fibroxanthoma, also known as cutaneous MFH, is rarely metastasized and presents a benign clinical course. Since there is a great difference between the prognosis of MFH and atypical fibroxanthoma, precise diagnosis of the primary tumor is essential.


Atypical fibroxanthoma; CD99; In-transit metastasis; Malignant fibrous histiocytoma

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