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Mediators Inflamm. 2011;2011:493925. doi: 10.1155/2011/493925. Epub 2011 Sep 18.

DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response.

Author information

1
Department of Pediatrics, Kaplan Medical Center, P.O. Box 1, Rehovot, Israel. ettie_g@clalit.org.il

Abstract

BACKGROUND:

It is currently recommended that diet of pregnant mothers contain 200-300 mg DHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response.

METHODS:

60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production.

RESULTS:

CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group. Proportion of CD4 and CD8 cells producing IFN(γ) significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells. Immunoglobulins and anti-HBs levels did not differ between groups.

CONCLUSIONS:

In infants of mothers receiving DHA supplementation, a higher percentage of CD4 naïve cells and decreased CD4 and CD8 IFN(γ) production is compatible with attenuation of a proinflammatory response.

PMID:
21941411
PMCID:
PMC3175709
DOI:
10.1155/2011/493925
[Indexed for MEDLINE]
Free PMC Article

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