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Nat Rev Cancer. 2011 Sep 23;11(10):708-18. doi: 10.1038/nrc3124.

Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping.

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1
Medicinal Bioconvergence Research Center, WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea. sungkim@snu.ac.kr

Erratum in

  • Nat Rev Cancer. 2011 Nov;11(11):813.

Abstract

Over the past decade, the identification of cancer-associated factors has been a subject of primary interest not only for understanding the basic mechanisms of tumorigenesis but also for discovering the associated therapeutic targets. However, aminoacyl-tRNA synthetases (ARSs) have been overlooked, mostly because many assumed that they were simply 'housekeepers' that were involved in protein synthesis. Mammalian ARSs have evolved many additional domains that are not necessarily linked to their catalytic activities. With these domains, they interact with diverse regulatory factors. In addition, the expression of some ARSs is dynamically changed depending on various cellular types and stresses. This Analysis article addresses the potential pathophysiological implications of ARSs in tumorigenesis.

PMID:
21941282
DOI:
10.1038/nrc3124
[Indexed for MEDLINE]

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