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Trends Immunol. 2011 Nov;32(11):524-31. doi: 10.1016/j.it.2011.08.007. Epub 2011 Sep 21.

Targeting B cell responses in universal influenza vaccine design.

Author information

1
Committee on Immunology, The University of Chicago, Chicago, IL, USA.

Abstract

Since its first administration in the 1940s, the influenza vaccine has provided tremendous relief against influenza infections. However, time has revealed the ultimate limit of the vaccine and the call for its reinvention has now come, just as we are beginning to appreciate the antibody immune responses vital in preventing infections. New strategies to design the influenza vaccine rely on selectively inducing broadly neutralizing antibodies that are specific for highly conserved viral epitopes. Such approaches take us away from the limited range of protection provided by current seasonal influenza vaccines and towards a future with a pan-influenza vaccine capable of providing universal strain coverage.

PMID:
21940217
PMCID:
PMC3212832
DOI:
10.1016/j.it.2011.08.007
[Indexed for MEDLINE]
Free PMC Article

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