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Drug Resist Updat. 2011 Dec;14(6):251-9. doi: 10.1016/j.drup.2011.08.003. Epub 2011 Sep 22.

Slipping and sliding: frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance.

Author information

1
Department of Virology and Immunology, Texas Biomedical Research Institute and Southwest National Primate Research Center, 7620 N.W. Loop 410, San Antonio, TX 78227, USA. agriffiths@txbiomed.org

Abstract

Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.

PMID:
21940196
PMCID:
PMC3195865
DOI:
10.1016/j.drup.2011.08.003
[Indexed for MEDLINE]
Free PMC Article

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