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Vaccine. 2011 Nov 3;29(47):8615-8. doi: 10.1016/j.vaccine.2011.09.015. Epub 2011 Sep 20.

Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media.

Author information

1
Department of Virology, University of Tampere, Tampere, Finland. elina.m.seppala@uta.fi

Abstract

BACKGROUND:

The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children.

METHODS:

Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12 months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24 months.

RESULTS:

Otitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6-18 months (IRR=0.76 [95% CI 0.59-0.94], P=0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19-0.71], P=0.003).

CONCLUSIONS:

OPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses.

PMID:
21939720
PMCID:
PMC7127548
DOI:
10.1016/j.vaccine.2011.09.015
[Indexed for MEDLINE]
Free PMC Article

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