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Neuropsychopharmacology. 2011 Dec;36(13):2589-602. doi: 10.1038/npp.2011.220. Epub 2011 Sep 21.

Depression, antidepressants, and neurogenesis: a critical reappraisal.

Author information

1
Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular zone of the dentate gyrus is regulated negatively by stressful experiences and positively by treatment with antidepressant drugs and (2) that alterations in the rate of neurogenesis play a fundamental role in the pathology and treatment of major depression. This hypothesis is supported by important experimental observations, but is challenged by equally compelling contradictory reports. This review summarizes the phenomenon of adult hippocampal neurogenesis, the initial and continued evidence leading to the development of the neurogenesis hypothesis of depression, and the recent studies that have disputed and/or qualified those findings, to conclude that it can be affected by stress and antidepressants under certain conditions, but that these effects do not appear in all cases of psychological stress, depression, and antidepressant treatment.

PMID:
21937982
PMCID:
PMC3230505
DOI:
10.1038/npp.2011.220
[Indexed for MEDLINE]
Free PMC Article

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