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Curr Opin Microbiol. 2011 Oct;14(5):593-8. doi: 10.1016/j.mib.2011.09.002. Epub 2011 Sep 19.

Heterogeneous bacterial persisters and engineering approaches to eliminate them.

Author information

1
Howard Hughes Medical Institute, Department of Biomedical Engineering and Center for BioDynamics, Boston University, Boston, MA 02215, USA.

Abstract

Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.

PMID:
21937262
PMCID:
PMC3196368
DOI:
10.1016/j.mib.2011.09.002
[Indexed for MEDLINE]
Free PMC Article

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