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Can J Vet Res. 1990 Apr;54 Suppl:S57-62.

Molecular aspects of some virulence factors of Haemophilus somnus.

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Department of Pathology, UCSD Medical Center 92103.


Several virulence factors of Haemophilus somnus have been investigated, but to a varying extent. It is known that some isolates are more virulent than others. Factors associated with virulence include attachment to vaginal epithelial cells, turbinate cells or embryos; serum resistance; growth stimulation by normal flora; interference with phagocyte function; Fc receptors; and toxicity for several bovine cell types. Lipooligosaccharide and Fc receptors have been investigated at the molecular level and studies are in progress to relate their molecular structure to virulence.

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