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Biochem Soc Trans. 2011 Oct;39(5):1126-30. doi: 10.1042/BST0391126.

Bidirectional intracellular transport: utility and mechanism.

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1
Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

Bidirectional transport of intracellular cargo along microtubule tracks is the subject of intense debate in the motility field. In the present review, we provide an overview of the models describing the possible mechanisms driving intracellular saltatory transport, taking into account current experimental results that may at first seem contradictory. We examine the phenomenon of saltatory motion, in an attempt to interpret the mechanistic debate in terms of the utility of saltatory motion.

PMID:
21936776
PMCID:
PMC3410738
DOI:
10.1042/BST0391126
[Indexed for MEDLINE]
Free PMC Article
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