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Integr Biol (Camb). 2011 Oct;3(10):972-81. doi: 10.1039/c1ib00044f. Epub 2011 Sep 21.

Red blood cell dynamics: from cell deformation to ATP release.

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1
Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, USA.

Abstract

The mechanisms of red blood cell (RBC) deformation under both static and dynamic, i.e., flow, conditions have been studied extensively since the mid 1960s. Deformation-induced biochemical reactions and possible signaling in RBCs, however, were proposed only fifteen years ago. Therefore, the fundamental relationship between RBC deformation and cellular signaling dynamics i.e., mechanotransduction, remains incompletely understood. Quantitative understanding of the mechanotransductive pathways in RBCs requires integrative studies of physical models of RBC deformation and cellular biochemical reactions. In this article we review the physical models of RBC deformation, spanning from continuum membrane mechanics to cellular skeleton dynamics under both static and flow conditions, and elaborate the mechanistic links involved in deformation-induced ATP release.

PMID:
21935538
DOI:
10.1039/c1ib00044f
[Indexed for MEDLINE]
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