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Nat Immunol. 2011 Sep 20;12(10):933-40. doi: 10.1038/ni.2094.

Malignant pirates of the immune system.

Author information

1
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Abstract

At great human cost, cancer is the largest genetic experiment ever conducted. This review highlights how lymphoid malignancies have genetically perverted normal immune signaling and regulatory mechanisms for their selfish oncogenic goals of unlimited proliferation, perpetual survival and evasion of the immune response.

PMID:
21934679
DOI:
10.1038/ni.2094
[Indexed for MEDLINE]

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