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EMBO J. 2011 Sep 20;30(19):3885-94. doi: 10.1038/emboj.2011.340.

FOXA1: master of steroid receptor function in cancer.

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1
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

Abstract

FOXA transcription factors are potent, context-specific mediators of development that hold specialized functions in hormone-dependent tissues. Over the last several years, FOXA1 has emerged as a critical mediator of nuclear steroid receptor signalling, manifest at least in part through regulation of androgen receptor and oestrogen receptor activity. Recent findings point towards a major role for FOXA1 in modulating nuclear steroid receptor activity in breast and prostate cancer, and suggest that FOXA1 may significantly contribute to pro-tumourigenic phenotypes. The present review article will focus on the mechanisms, consequence, and clinical relevance of FOXA1-mediated steroid nuclear receptor signalling in human malignancy.

PMID:
21934649
PMCID:
PMC3209791
DOI:
10.1038/emboj.2011.340
[Indexed for MEDLINE]
Free PMC Article
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