Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Rheumatol. 2011 Nov;23(6):568-73. doi: 10.1097/BOR.0b013e32834bac92.

Regeneration versus fibrosis in skeletal muscle.

Author information

1
Center for Genetic Muscle Disorders, The Kennedy Krieger Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Abstract

PURPOSE OF REVIEW:

This review evaluates recently published literature examining various muscle tissue cells and their modulators that determine whether injured skeletal muscle will fully regenerate or become fibrotic.

RECENT FINDINGS:

Muscle regeneration is a complex process involving several interacting cell types. Macrophages initiate a cytokine response to injury that both directs the subsequent inflammatory response and promotes nonmyeloid proliferation. Muscle cells and their progenitors produce autocrine and paracrine growth factors that help inhibit or stimulate muscle growth and regeneration. Cells of the connective tissue, including fibroblasts and newly described fibro/adipogenic progenitors, can support myogenic cells and remodel the extracellular matrix. However in certain environments, fibrosis can become a self-perpetuating process leading to incomplete muscle regeneration.

SUMMARY:

Several cell types are involved in the muscle repair process, interacting through multiple signaling molecules and pathways. This provides a richness of potential therapeutic targets to reduce fibrosis and facilitate skeletal muscle regeneration.

PMID:
21934499
DOI:
10.1097/BOR.0b013e32834bac92
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center